Multiple sclerosis and spasticity

Understanding multiple sclerosis and spasticity

Multiple sclerosis is a neurological disease that can cause spasticity, weakness, pain, fatigue and balance problems. Disease-modifying treatment and follow-up belong with a specialist team and should never be stopped without that team.

Medical cannabis and multiple sclerosis and spasticity

The most structured evidence mainly concerns nabiximols, a standardized THC:CBD product, added to treatment for persistent spasticity. Assessment should remain coordinated with neurology and distinguish spasticity, pain and other symptoms.

What the evidence shows

Reviews and meta-analyses report improvement in patient-rated spasticity for some people using nabiximols in addition to usual treatment. Objective clinical measures and individual response may differ.

What it does not establish

Findings for a standardized medicine cannot automatically be generalized to all oils, flower or cannabis concentrations. Cannabinoids do not modify the course of multiple sclerosis.

Points to discuss during the assessment

• The targeted symptom: spasticity, spasms or pain
• Neurology follow-up and disease-modifying treatment
• Balance, falls, cognition and fatigue
• Current antispasticity or sedating medication

Important precautions

• Adverse effects can include drowsiness, dizziness, impaired attention, anxiety or a faster heart rate.
• THC can impair driving and the operation of machinery; never drive while impaired.
• Particular caution is required during pregnancy or breastfeeding, with some heart conditions, or with a personal or family history of psychosis.
• Tell the practitioner about all current medications and supplements so possible interactions can be assessed.